Supporting Gut Barrier Health: Clinical Evidence from elénzia’s PoZibio® Gut Wellness Study
Research scientist Godsfavour Oghifo looks at the results of elénzia’s PoZibio® Gut Wellness Study
By elenzia / January 29th 2026 / Lifestyle
For more than ten years, I lived with the ups and downs of peptic ulcer and acid reflux. I knew the routine all too well: the burning discomfort after meals, the restless nights, and the familiar reach for antacids or a proton pump inhibitor just to make it through the day. Like many people, I focused on managing the symptoms rather than understanding what was really happening inside my gut.
Digestive discomfort is far more common than most people realize. Bloating, irregular bowel habits, or that burning feeling after meals can quietly drain your energy, affect your mood, and interfere with daily life. Many of us either learn to “cope” or chase short-term remedies without addressing the underlying cause.
Science is now helping us see a clearer picture. A lot of our digestive comfort comes from the health and integrity of the gut’s protective mucus layer, a vital barrier that helps digestion run smoothly and shields the lining from irritation. Over time, things like antibiotics, infections, stress, diet, and even aging can weaken this layer. When that happens, it can trigger the very symptoms so many of us endure every day without really knowing why.
What Is the Gut Barrier and Why Does It Matter?
The gut lining consists of epithelial cells sealed by tight junction proteins and covered by a protective mucus layer secreted by goblet cells. The major structural protein in this layer is Mucin-2 (Muc2). This mucus barrier physically separates gut microbes from the intestinal wall, preventing inflammation and immune activation (Johansson, 2012; König et al., 2016).
When the mucus layer becomes thinner, bacteria and bacterial components can come into direct contact with gut tissue, increasing permeability and promoting “leaky gut”, which has been observed in aging populations and in chronic digestive discomfort (Elderman et al., 2017; Vemuri et al., 2018).
A compromised mucus layer can lead to inflammation and symptoms such as bloating, abdominal discomfort, constipation, and food sensitivity.
PoZibio®: A New Approach to supporting the Gut Barrier
Traditional probiotics are designed to add beneficial bacteria to the gut.
However, emerging research suggests that postbiotics, bioactive molecules produced by beneficial bacteria, may directly support the gut lining in a more reliable and targeted way. One such postbiotic is PoZibio®, derived from Lactobacillus paracasei D3-5.
Unlike probiotics, PoZibio® does not need to survive digestion or colonize the gut. One of its active compounds, Lipoteichoic Acid (LTA), works directly on the cells that produce the protective mucus. Research has shown that PoZibio® activates Toll-Like Receptor 2 on goblet cells, which triggers increased Mucin-2 production. This helps rebuild the protective mucus layer and support tighter barrier function.
In other words, PoZibio® helps the gut restore its natural protective lining, making digestion feel calmer and more stable.
The Gut Wellness Study: Real-World Evidence
An 8-week randomized, placebo-controlled Study conducted by the research team at elénzia MEDICAL, evaluated the effects of PoZibio® in adults with ongoing digestive discomfort. Participants took either PoZibio® 100 mg, PoZibio® 340 mg or placebo.
Throughout the study, participants tracked their symptoms and daily wellbeing using elénzia’s bespoke digital research platform – the Ingredients for Life™ app. This advanced app seamlessly integrated clinically validated assessment tools, including the Gastrointestinal Symptom Rating Scale (GSRS) and the Digestion-associated Quality of Life Questionnaire (DQLQ), which were delivered bi-weekly to participants. This digital approach ensured real-time, high-quality data capture and reflects elénzia’s commitment to innovative, tech-enabled clinical research in nutritional science.
Gut Wellness Study Results: Improvements in Digestive Comfort and Wellbeing
Reduced Digestive Symptoms up to 41%
Those taking PoZibio® experienced up to a 41% reduction in overall gut symptoms compared to just 19% in the placebo group. Many participants described feeling lighter, less bloated, and more comfortable day to day.
Relief from Indigestion
By week 8, indigestion symptoms such as bloating, excessive gas, and post-meal discomfort improved by around 45% in those taking the higher dose of PoZibio®. Even the lower dose group saw close to 40% improvement, compared to only 13% in those who didn’t take PoZibio®.
Improved Bowel Regularity
Constipation symptoms improved significantly: up to 43% improvement in the higher-dose group and 23% improvement in the lower dose group, while the placebo group saw no benefit.
Enhanced digestion-related quality of life
Digestive health affects more than just the gut, it influences how people eat, socialise, and feel day to day. Using the Digestion-Associated Quality of Life Questionnaire (DQLQ), the study captured how participants’ digestive symptoms impacted their relationship with food and drink, emotional wellbeing, and social or physical activities.
After 8 weeks, those supplementing with PoZibio® reported around a 50% improvement in quality-of-life scores, compared to only 12% in the placebo group. Participants said they felt more confident eating a wider range of foods, experienced less discomfort after meals, and felt more comfortable participating in everyday social and physical activities.
Improved overall digestive health
More than 6 in 10 participants taking PoZibio® noticed at least a 30% improvement in their digestive health overall and for indigestion-related issues, this number was even higher, reaching 75% in the higher-dose group. Importantly, PoZibio® was very well tolerated, with no serious adverse events reported throughout the study.
Participant Experiences from the Gut Wellness Study
Beyond the numbers, the personal experiences shared by participants highlight the real-world benefits of PoZibio® supplementation. Many described noticeable improvements in comfort, regularity, and overall wellbeing which is consistent with the clinical outcomes observed.
Participants taking the higher 340 mg dose often reported significant relief from digestive discomfort:
“I felt less bloated and less constipated; overall I just felt better.” – Female, 60
“I was always constipated and that has now stopped since taking this. I was bloated and feeling sluggish, and that’s no longer happening.” – Female, 41
“I can go to the toilet easier and feel much less bloated.” – Female, 48
Those on the 100 mg dose also experienced meaningful benefits:
“If I remembered to take the capsule just before food, I wasn’t bloated like I usually am in the morning or evening.” – Female, 32
“Less bloating, and when it happened, it wasn’t painful. I have better confidence in my body and less anxiety.” – Female, 33
“I’ve had a significant reduction in acid problems. I can eat foods I haven’t tolerated in years, like pickles and bread, without burping or discomfort. Everything feels so much calmer. I feel like I’ve been reset, rebooted.” – Female, 65
Together, these voices reflect what the data already showed with a consistent pattern of improved digestion, comfort, and quality of life across participants supplementing with PoZibio®, which aligns with its mechanism of action in supporting gut barrier integrity and overall digestive health. This study reinforces an important idea:
Improving gut comfort isn’t just about what you avoid, it’s about what you rebuild.
From Science to Solution: The Evolution of elénzia FIX®
The success of the Gut Wellness Study provided the scientific foundation for elénzia FIX®, a formulation that translates clinical insights into daily wellness. Guided by the results observed with PoZibio®, our medical research team enhanced the formula with a synergistic blend of nutrients designed to target multiple aspects of gut health simultaneously.
At elénzia, our mission is to translate cutting-edge science into meaningful daily health solutions. With elénzia FIX®, we’ve created more than a supplement, it’s a clinically inspired formulation designed to soothe, repair, and restore balance to the gut. Backed by real-world data and developed through our advanced digital research platform, elénzia FIX® represents the next step in personalised gut health innovation, helping you feel lighter, more comfortable, and more like yourself again.
