A holistic, proactive approach to year-round immune health

Immune health is not just about responding when illness appears. It is about staying resilient, balanced, and supported every day. elénzia IMMUNITY® takes a holistic, proactive approach to year-round immune care, bringing together clinically studied ingredients that work from the inside out to support how your immune system functions.  

Everyday life can quietly challenge immune readiness. Modern science shows that chronic stress, poor sleep, low vitamin D, and an imbalanced gut can all weaken the body’s natural defences, making it harder to stay healthy7,8. elénzia IMMUNITY® addresses these challenges through a multi-pillar formula that supports stress and sleep balance, trains innate immune cells, nourishes gut health, and maintains vitamin D levels, helping your immune system stay steady, resilient, and ready year-round. 

Affron® (Crocus sativus L.) — Stress and Sleep Support 

Affron® is a highly standardized saffron extract that delivers consistent levels of key bioactive compounds, including crocins and safranal. These compounds support the balance of key neurotransmitters such as serotonin, dopamine, and norepinephrine, and help regulate melatonin, contributing to improved sleep quality, stress resilience, and positive mood without causing daytime drowsiness1,2.  

By supporting emotional wellbeing, stress management, and aspects of sleep quality, affron® targets everyday lifestyle factors that are known to influence how resilient your immune system feels and responds1,2. 

Clinical Evidence 

• In a 12week study of 202 adults with subclinical low mood, 72 % of participants taking 28 mg affron® daily showed clinically meaningful improvements in emotional wellbeing, compared with 54% in the placebo group. Participants also experienced an average 53% reduction in depressive and stress symptoms on the Depression Anxiety Stress Scale (DASS21). Benefits began to appear as early as week five1.  

• In a 4-week randomized, double-blind, placebo-controlled trial, 128 adults with self-reported low mood received 28 mg/day, 22 mg/day, or placebo. Those taking 28 mg/day experienced a 35–40% reduction in negative mood and stress symptoms on the POMS Total Mood Disturbance scale compared with placebo2. 

BetaVia™ Complete— Immune training beta1,3glucans 

BetaVia™ Complete is a unique, microalgae-derived beta-1,3-glucan complex containing more than 50% beta-1,3-glucans, alongside naturally occurring proteins, fatty acids, vitamins, minerals, and carotenoids. This rich composition supports immune health through multiple, complementary pathways3. 

BetaVia™ Complete helps prime innate immune cells, the body’s first line of natural defence, improving immune readiness rather than overstimulating immune responses. At the same time, it supports the growth of beneficial gut bacteria, including Lactobacillus and Bifidobacteria, within the gut microbiota, which houses most of the body’s immune cells. It also helps protect the health of intestinal cells, supporting gut barrier integrity so the gastrointestinal tract can function effectively as both a physical barrier and an immune shield3. 

These mechanisms are supported by clinical and preclinical research across the respiratory and gastrointestinal systems. 

Clinical Evidence 

• In a 90day randomized, doubleblind, placebocontrolled clinical trial, adults taking BetaVia™ complete reported 70 % fewer upper respiratory tract infection (URTI) symptoms compared with placebo, along with 3.3 fewer sick days and 10 fewer days with URTI symptoms over the study period (measured by the validated Wisconsin Upper Respiratory Symptoms Survey)3. These outcomes demonstrate meaningful reductions in illness symptom burden and duration, supporting its role in proactive immune resilience. 

VD3® 250% NRV (Vegan Vitamin D3) — Supporting immune regulation and resilience 

VD3® is a microencapsulated, algae-sourced vitamin D3 (cholecalciferol) that is chemically identical to animal-derived forms but comes from a sustainable, traceable vegan source and is designed for reliable absorption4. 

Vitamin D is essential for both innate and adaptive immune responses, helping the body respond efficiently to challenges while maintaining immune balance4.  

Clinical Evidence 

• In a large meta-analysis of 25 randomized, doubleblind, placebocontrolled trials (over 10,900 participants), vitamin D supplementation was shown to reduce the overall risk of acute respiratory tract infection (ARI) by about 12% compared with placebo. Protective effects were strongest in participants receiving daily or weekly vitamin D but not bolus doses, especially in those with low baseline vitamin D levels4. 

• Another Large meta-analysis of 43 clinical trials including over 48,000 participants show that daily vitamin D supplementation can reduce the risk of acute respiratory infections by 22–30%, particularly in children, adolescents, and adults taking 400–1000 IU daily5. 

• Evidence from a study in 25 male taekwondo athletes, aged 19–22 years with vitamin D insufficiency demonstrated that supplementation with 5000IU/day of Vitamin D3 increased serum vitamin D levels by over 250%, which was associated with 18–20% fewer upper respiratory tract infection symptoms during winter training compared with placebo6. 

How elénzia IMMUNITY™ Formula Works Together 

Together, these three ingredients form a multi-pillar, systems-based approach to immune health: 

Why elénzia IMMUNITY® Stands Out 

Unlike most generic immune supplements that target just one aspect of immunity, elénzia IMMUNITY® takes a holistic, multi-level approach. It works from the inside out to strengthen, balance, and support the immune system so it can respond effectively to everyday challenges. Clinically studied, sustainably sourced, and carefully dosed, elénzia IMMUNITY® delivers a complete and efficient approach to proactive immune health, helping your body stay strong, resilient, and performing at its best every day. 

References 

1. Lopresti AL, Smith SJ, Marx W, Díez-Municio M, Morán-Valero MI. An Examination into the Effects of a Saffron Extract (Affron) on Mood and General Wellbeing in Adults Experiencing Low Mood: A Randomized, Double-Blind, Placebo-Controlled Trial. J Nutr. 2025 Jul;155(7):2300-2311. doi: 10.1016/j.tjnut.2025.05.024. Epub 2025 May 23. PMID: 40414301. 
2. Kell G, Rao A, Beccaria G, Clayton P, Inarejos-García AM, Prodanov M. affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complement Ther Med. 2017 Aug;33:58-64. doi: 10.1016/j.ctim.2017.06.001. Epub 2017 Jun 13. PMID: 28735826. 
3. Evans M, Falcone PH, Crowley DC, Sulley AM, Campbell M, Zakaria N, Lasrado JA, Fritz EP, Herrlinger KA. Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2019; 11(12):2926. https://doi.org/10.3390/nu11122926 
4. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017 Feb 15;356:i6583. doi: 10.1136/bmj.i6583. PMID: 28202713; PMCID: PMC5310969. 
5. Jolliffe DA, Camargo CA Jr, Sluyter JD, et al. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials. Lancet Diabetes Endocrinol. 2021 May;9(5):276-292. doi: 10.1016/S2213-8587(21)00051-6. Epub 2021 Mar 30. PMID: 33798465. 
6. Jung HC, Seo M-W, Lee S, Kim SW, Song JK. Vitamin D3 Supplementation Reduces the Symptoms of Upper Respiratory Tract Infection during Winter Training in Vitamin D-Insufficient Taekwondo Athletes: A Randomized Controlled Trial. International Journal of Environmental Research and Public Health. 2018; 15(9):2003. https://doi.org/10.3390/ijerph15092003 
7. Johnson CR, Thacher TD. Vitamin D: immune function, inflammation, infections and auto-immunity. Paediatr Int Child Health. 2023 Nov;43(4):29-39. doi: 10.1080/20469047.2023.2171759. Epub 2023 Mar 1. PMID: 36857810. 
8. Jia H, Guo X, Wei Y, Can C, He N, Zhang H, Yang X, Wu H, Liu W, Ma D. Chronic stress, gut microbiota, and immunity: interconnections and implications for health. Mol Cell Biochem. 2025 Dec;480(12):5995-6014. doi: 10.1007/s11010-025-05376-y. Epub 2025 Aug 27. PMID: 40864384.