elénzia ENHANCE®

A Holistic Approach to Gut Health

A healthy gut is essential for immune balance, nutrient absorption, and overall wellbeing. When gut function is compromised, it can lead to symptoms such as acid reflux, bloating, abdominal discomfort and irregularities. In the UK, nearly 40% of the population experiences gastrointestinal issues at any given time, placing a significant burden on both individuals and healthcare resources.

To support a balanced digestive system, elénzia has developed elénzia FIX®, a carefully formulated gut health supplement that takes a holistic approach to digestive wellness, soothing, repairing, and restoring the gut for optimal function.

PoZibio®: A Clinically Studied Postbiotic for Gut Barrier Support

At the heart of elénzia FIX® is PoZibio®, a postbiotic backed by years of clinical research. PoZibio® is a patented postbiotic, derived from a heat-treated strain of Lactobacillus paracasei (D3-5) with Lipoteichoic Acid (LTA) as the key bioactive molecule.¹

Unlike probiotics (living organisms), which often need to survive the digestive tract and sometimes rely on colonising the gut to have an effect, PoZibio® contains the beneficial structural components of beneficial bacteria that delivers its benefits without requiring the bacteria to be alive. This means the effect is consistent, predictable, and stable.

Mechanistically, LTA stimulates goblet cells in the gut to increase Mucin-2 production, strengthening the mucus layer and tight junctions. This supports gut lining repair, reduces leaky gut, and helps calm inflammation which translates into less bloating, discomfort and digestive sensitivity.¹

In our randomized, placebo-controlled trial of 82 adults, both standard (100 mg) and higher-dose (340 mg) PoZibio® groups experienced significant reductions in gastrointestinal symptoms and notable improvements in day-to-day quality of life compared to placebo over a period of eight weeks.

Key findings included (Internal clinical data, elénzia MEDICAL, 2025):

Real People, Real Relief

One of the most encouraging parts of our research was how many people felt a genuine difference in their day-to-day comfort. More than 6 in 10 people taking PoZibio® experienced a noticeable improvement in their digestion overall.

These results highlight PoZibio®’s potential to support gut barrier integrity and wellbeing, making it the cornerstone of elénzia FIX®’s holistic formula.

Supporting Ingredients for Comprehensive Gut Support

While PoZibio® leads the way, elénzia FIX® is designed as a holistic gut-support blend, combining ingredients that complement each other for maximal benefit.

Marshmallow Root 5:1 Extract: Soothing the Digestive Mucosa

Marshmallow Root extract is rich in polysaccharides like Arabinogalactans and Rhamnogalacturonans that form a gentle, soothing gel-like layer over irritated tissue^2,3. This makes Marshmallow Root particularly valuable during periods of digestive discomfort.¹
This traditional botanical is supported by modern evidence for:

• Reducing irritation along the digestive tract²
• Supporting mucosal hydration³
• Promoting digestive comfort in those with sensitivity or flare-ups²

Aloe Vera 200:1 Extract: Supporting Gut Tissue Repair

Aloe Vera contains bioactive compounds like acemannan and glucomannan which support mucosal healing and help moderate inflammation^5,6. Its gentle restorative properties complement both L-Glutamine and NAG in supporting the gut’s physical defences⁶. Clinical research shows Aloe Vera may:

• Activate fibroblast and epithelial repair⁵
• Stimulate tight junction recovery⁶
• Support repair of the gut’s protective mucosal layer⁶
• Reduce local inflammation⁵
• Promote smoother, more comfortable digestion^5,6

 

N-Acetyl D-Glucosamine: Structural Support for Mucosal Defence

N-Acetyl D-Glucosamine (NAG) is a building block of the protective mucosal layer that lines the intestines. A healthy mucosal layer acts as a physical and biochemical shield, helping prevent irritation and supporting balanced microbial activity⁷. NAG works particularly well alongside PoZibio® to reinforce both the cellular structure and surface protection of the gut lining.⁹
Evidence suggests that NAG may:

• Enhance production of mucin, which coats and protects the gut wall⁸
• Support the repair of irritated or compromised mucosal tissue⁸
• Contribute to improved intestinal comfort in individuals with digestive sensitivity⁸

 

L-Glutamine: Repairing and Strengthening the Gut Lining

L-Glutamine is the primary fuel source for the cells that form the intestinal barrier. When the gut is irritated or under stress (for example, during digestive discomfort, illness, or inflammation), the body may not produce enough glutamine to maintain and repair this protective lining.^9,10 Research shows that L-Glutamine helps to:

• Reinforce tight junctions in the intestinal wall, supporting barrier integrity and helping reduce intestinal permeability (“leaky gut”)^10,11
• Reduce inflammatory signalling within the gut environment^10,11
• Promote repair and renewal of intestinal tissue^9,11
• Support healthy immune activity within the gut mucosa^9,10

Clinically, this translates to better resilience of the gut lining, improved digestive comfort, and a more stable foundation for immune function^9,10,11. In a randomized, placebo‑controlled trial, supplementation with L‑glutamine at a dosage of 15 g per day over 8 weeks significantly improved intestinal permeability and gastrointestinal symptoms in adults⁴.

Zinc, Copper and Vitamin D3: Immune and Barrier Function Support

These essential micronutrients contribute to healthy immune signalling and tissue repair within the gut. Together, they help the gut respond to stress without overreacting, which is key in maintaining comfort and stability.

• Zinc supports barrier integrity and is required for cellular repair and enzymatic processes involved in gut healing¹².
• Copper works alongside zinc to maintain immune balance and antioxidant defense¹³.
• Vitamin D3 supports immune regulation and has been linked to improved gut immune tolerance and reduced inflammation¹⁴.

 

How elénzia FIX® Formula Works Together

elénzia FIX® doesn’t just relieve symptoms but is designed to address gut health on multiple levels:

 

Function	Key Ingredients	What This Means for You
Soothe	Marshmallow Root	Forms a soft protective layer to calm irritation and help keep the gut lining hydrated.
Soothe	Aloe Vera	Supports beneficial gut bacteria, helps repair the gut lining, and eases local inflammation.
Protect	PoZibio®	Strengthens the gut’s natural barrier and helps reduce intestinal permeability (“leaky gut”).
Protect	N-Acetyl-D-Glucosamine	Builds a strong mucus shield to protect the gut lining and support balanced inflammatory responses.
Restore	L-Glutamine	Fuels gut cells and supports repair of the digestive lining for comfort and balance.
Restore	Zinc & Copper	Support tissue repair, antioxidant defences, and resilience of the gut lining.
Restore	Vitamin D3	Helps maintain gut barrier integrity and supports balanced immune signalling.

 

Together, this formulation addresses multiple aspects of gut health, from structural support to immune modulation, providing a comprehensive approach to digestive wellbeing.

Evidence-Based Approach to Digestive and Gut Health Support

Unlike generic supplements, elénzia FIX® is grounded in science. With patented ingredients supported by crucial nutrients provided at clinically relevant dosages. The efficacy of PoZibio® has been demonstrated in a randomized controlled study, and the supporting ingredients have well-established roles in gut integrity and immune support.

This combination offers a practical, evidence-backed solution for individuals looking to maintain gut health, manage digestive discomfort, and support their overall wellbeing naturally.

You can purchase elénzia FIX® now, here!

References

1. Wang S, et al. (2020). Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. Geroscience. https://pubmed.ncbi.nlm.nih.gov/31814084/
2. Hostanska K, Daum G, Saller R. Althaea officinalis L. (Marshmallow root) polysaccharides: immunomodulatory and anti-inflammatory effects. 2002;9(4):302‑308. https://pubmed.ncbi.nlm.nih.gov/12062776/
3. McKoy M, et al. The mucilage of Althaea officinalis: chemical composition and effects on intestinal epithelial cells. J Ethnopharmacol. 2012; 143:86‑91. https://pubmed.ncbi.nlm.nih.gov/22361455/
4. Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, Verne GN. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. Gut. 2019 Jun;68(6):996-1002. doi: 10.1136/gutjnl-2017-315136. https://pmc.ncbi.nlm.nih.gov/articles/PMC9549483/
5. Jettanacheawchankit S, et al. Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing. J Pharmacol Sci. 2009;109(4):525-31. https://doi.org/10.1254/jphs.08204FP
6. Kim SH, Shim KS, Song Y, et al. Pharmacological and therapeutic activities of Aloe vera and its major active constituent acemannan. Food Suppl Biomater Health. 2023;3(2):e8. https://doi.org/10.52361/fsbh.2023.3.e8
7. Paone C, Cani PD. The mucus barrier and gut microbiome in intestinal health and disease. 2020;69(12):2232‑2243. https://gut.bmj.com/content/69/12/2232
8. Deters A, et al. N-acetyl-D-glucosamine oligosaccharides induce mucin secretion in ex vivo intestinal tissue. 2008;18(7):555‑562. https://pubmed.ncbi.nlm.nih.gov/18237467/
9. Reeds PJ. Glutamine and the bowel. JPEN J Parenter Enteral Nutr. 2001;25(6 Suppl):S70‑S74. https://www.sciencedirect.com/science/article/pii/S002231662214592X
10. Rao RK. Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. Curr Opin Clin Nutr Metab Care. 2011;14(6):611‑617. PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369670/
11. Lu TL, et al. Supplementation of L-glutamine enhanced mucosal immunity and barrier function in athletes. J Int Soc Sports Nutr. 2024;21:11. PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10783826/
12. Powell SR. The antioxidant properties of zinc. J Nutr. 2000;130(5S Suppl):1447S‑1454S. https://pubmed.ncbi.nlm.nih.gov/10736385/
13. Uriu-Adams JY, Keen CL. Copper, oxidative stress, and human health. Mol Aspects Med. 2005;26(4‑5):268‑298. https://pubmed.ncbi.nlm.nih.gov/16051337/
14. Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am. 2010;39(2):365‑379. https://pubmed.ncbi.nlm.nih.gov/20452222/

A Holistic Approach to Blood Glucose Management

elénzia CONTROL® offers a science-backed solution to the growing concern of blood glucose dysregulation, which affects nearly 25% of European adults and is linked to conditions like type 2 diabetes, PCOS, and cardiovascular disease (Eades CE., 2016). In response to this growing concern, the popularity of GLP-1 mimicking drugs like Ozempic has skyrocketed, offering a seemingly effortless solution to blood glucose control. Nevertheless, as the saying goes, if it sounds too good to be true, it probably is. At elénzia, we firmly believe that nature cannot be rushed; it is only supported. Consequently, our approach aims to foster holistic health improvement, empowering you to age beautifully.

With its holistic design, elénzia CONTROL® transcends the limitations of typical one-dimensional blood sugar management products, empowering women to achieve healthier glucose levels naturally. Let’s delve into the science behind CONTROL®.

Eriomin®: Three Human Clinical Studies, One Clear Conclusion

At the core of this innovative formulation lies Eriomin®, a proprietary lemon flavonoid complex with impressive clinical validation through three high-quality human studies. The research demonstrates remarkable consistency in results, establishing Eriomin® as a scientifically validated approach to blood glucose management. See some of the results below.

With 3 clinical trials showing consistent results across 178 participants, Eriomin® stands out as a science-backed, natural option for metabolic health. This innovative lemon flavonoid blend operates through a multi-pronged mechanism, addressing key aspects of metabolic function.

Firstly, it reduces hyperglycaemia by increasing natural GLP-1 levels, thereby improving glucose regulation. Secondly, it tackles oxidation and systemic inflammation by lowering markers such as IL-6 and TNF-α. Finally, it positively influences gut health by modulating microbiota composition, reducing harmful bacteria associated with dysbiosis while promoting the growth of beneficial microorganisms (Ramos et al., 2023). Importantly, throughout these studies, Eriomin® has proven to be safe, with no adverse events reported, a far cry from the experience of so many who take GLP-1 receptor drugs.

Bitter Melon Extract: Redeveloping fat utilisation

Bitter Melon (Momordica charantia L.) is gaining scientific validation with numerous peer-reviewed and published journals discussing the anti-diabetic effects of bitter melon extract. Its bioactive compounds, including Charantin and polypeptide-P, work to lower blood glucose levels. Charantin activates AMPK, improving glucose uptake and fat metabolism (aka burning), while polypeptide-P, known as “plant insulin,” supports pancreatic β-cell function (Richter et al., 2023). Furthermore, the anti-inflammatory effects, reduce markers like IL-6 and TNF-α, which drive insulin resistance (Dandawate et al., 2016).

Bitter Melon has been shown to help remap the bodies fat utilization, priming it for metabolic health in 3 main ways:

It actively promotes fatty acid oxidation, or “fat burning”, by increasing the expression of carnitine palmitoyltransferase-I (CPT-1) and acyl-CoA dehydrogenase enzymes in the liver and muscles.

It can suppress lipogenic genes – the ones responsible for creating new fat cells in your body – by downregulating fatty acid synthase, acetyl-CoA carboxylase-1, and lipoprotein lipase.

It supports healthy blood lipid levels by lowering levels of triglycerides and apolipoprotein B-100 whilst increasing the expression of uncoupling protein 1 (UCP1) in brown adipose tissue – our metabolically active fat that burns, rather than stores fat (Aslam et al., 2015).

However, Zhang et al, (2016) found that the microbiome influencing properties of Bitter Melon was a vital mechanism behind its lipid and cholesterol managing properties as mice that were also fed antibiotics had a diminished effect, reaffirming the importance of minimising antibiotic use.

The extract used in elénzia CONTROL® is equivalent to 2000mg of fresh bitter melon fruit per serving, providing a concentrated form of these bioactive compounds.

SILIPHOS® and Choline Bitartrate: Dual Support for Liver Function

The liver’s crucial role in glucose homeostasis is often overlooked, especially in blood glucose supplements, despite its unquestionable importance. Non-alcoholic fatty liver disease (NAFLD) affects an alarming 25-30% of adults globally, with notably higher prevalence in postmenopausal women. This condition directly influences glucose metabolism, as insulin resistance in the liver often precedes systemic insulin resistance (Younossi et al., 2023). Our blog titled “The Liver – The Hub of Blood Glucose Management” further outlines the importance of supporting this organ and why it is a significant part of elénzia CONTROL™.

SILIPHOS®: A silybin-phosphatidylcholine complex with up to 10 times greater bioavailability than standard milk thistle extracts.

Clinical studies have demonstrated that SILIPHOS® offers significantly greater bioavailability compared to standard milk thistle extracts, allowing for more effective delivery of silybin to target tissues. This enhanced bioavailability translates into greater antioxidant, anti-inflammatory, and antifibrotic effects than possible with a standard extract at such doses. Additionally, SILIPHOS® has shown promise in modulating metabolic pathways, reducing oxidative stress, and improving lipid profiles without significant side effects at clinically relevant doses. Its ability to safely protect liver cells and support metabolic function has even led to studies using SILIPHOS® with cancer patients, those with Non-Alcoholic Fatty Liver Disease (NAFLD) and adds to the evidence that milk thistle extracts are an ally against insulin resistance (Loguercio, C., & Festi, D. 2011; Siegel et al., 2014; MacDonald-Ramos et al., 2020).

Choline Bitartrate: Choline is a critical nutrient for cell structure and neurotransmitter synthesis but is also vital for liver function and metabolism. Officially recognised as an essential nutrient in 1998, the inadequate intake of it amongst men and particularly women is a cause for concern. As a key precursor for phosphatidylcholine synthesis, choline is integral to the formation of very low-density lipoproteins (VLDL), facilitating hepatic lipid export. Its deficiency can lead to a fatty liver (steatosis) due to impaired triglyceride secretion which if left unchecked can progress to fibrosis or cirrhosis. This nutrient’s multifaceted involvement in liver physiology underscores its importance in maintaining hepatic health and overall metabolic balance (Zeisel & da Costa, 2009; Corbin & Zeisel, 2012).

By targeting liver health, elénzia CONTROL® optimizes insulin clearance and sensitivity, creating a more favourable metabolic environment for overall glucose control.

elénzia CONTROL® addresses thyroid optimisation through 3 highly bioavailable and essential minerals:

Iodine serves as the fundamental building block for thyroid hormone synthesis. T4 (thyroxine) and T3 (triiodothyronine) cannot be produced without adequate iodine, as the “4” and “3” in their names refer to the number of iodine atoms each contains (Anastasia T., 2007). Even in Europe where iodized salt is commonplace, suboptimal iodine status remains surprisingly common, with studies showing up to 30% of women over 40 have inadequate intakes (Zimmermann MB and Andersson M., 2021).

Selenium plays a critical role in thyroid hormone metabolism. It’s an essential component of deiodinase enzymes that convert less active T4 to the more metabolically active T3. Additionally, selenium-dependent glutathione peroxidase enzymes protect the thyroid from oxidative damage during hormone synthesis (Köhrle J., 2005). Population studies show inverse correlations between selenium status and thyroid antibodies, suggesting a role in thyroid autoimmunity prevention (McGregor B, 2015).

Zinc completes the trio by enabling multiple aspects of thyroid function. It’s required for TSH signalling at the thyroid, affects T3 receptor sensitivity, and plays a role in the peripheral conversion of T4 to T3 (Maxwell C, and Volpe SL, 2007). Zinc deficiency correlates with reduced T3 levels and impaired glucose tolerance, potentially contributing to the metabolic slowdown many women experience during menopause (Freake HC et al., 2001).

This mineral triad supports optimal thyroid function, promoting healthy metabolism and glucose regulation. By targeting this often-overlooked aspect of metabolic health, elénzia CONTROL® offers a comprehensive approach to blood glucose management for menopausal women.

A Truly Integrative Approach

What distinguishes this formulation is not just its evidence-based ingredients but its systems-based approach to blood glucose management. Rather than targeting glucose levels directly through a single pathway, it addresses the underlying physiological systems that regulate metabolism: Natural GLP-1 production, liver protection and thyroid support).

For women navigating the metabolic challenges from pre- to post-menopause, this represents a welcome paradigm shift from conventional approaches—one that recognizes their unique physiological needs and addresses them through carefully selected, clinically validated ingredients working in concert to support overall metabolic harmony.

Want to hear more? elénzia Nutritional Scientist Godsfavour Oghifo wrote about the risks of Ozempic® for weight loss and reveals how CONTROL® offers a safer, natural GLP-1 solution for blood sugar balance and long-term health.